Cytochrome P450 enzymes (CYPs) are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs, toxins, and endogenous compounds. These enzymes are ...

Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin. While assessing ...

Cytochrome c nitrite reductase (NrfA) plays a crucial role in the nitrogen cycle, particularly in the process known as dissimilatory nitrate reduction to ammonium (DNRA). This enzyme catalyzes the ...

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Chemistry, Massachusetts Institute of Technology, Cambridge, ...

During pregnancy, SSRIs exhibit extensive pharmacokinetic variability that may influence their tolerability and efficacy. Specifically, compared to non-pregnant women, the activity of cytochrome P450 ...

A key finding of the study was the identification of Pseudoalteromonas fuliginea, a bacterium that can effectively degrade cyclohexane through a newly discovered cytochrome enzyme system ...

School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China ...

A key finding of the study was the identification of Pseudoalteromonas fuliginea, a bacterium that can effectively degrade cyclohexane through a newly discovered cytochrome enzyme system, referred to ...

Microbial factories provide a sustainable alternative to tree sap for producing elusive plant molecules, offering new ...

The team evaluated more than 4,000 clones before identifying an enzyme S N Ar1.3 that contains six mutations and is 160-fold more active than the parent enzyme.