Table 1 Transaminase elevations in Paradisi and Venturoli 1 and other studies 10 Full size table Cyproterone acetate and spironolactone are the main antiandrogenic alternatives for low-dose flutamide.

Factors such as older age, female sex, and exposure to three high-dose progestogens (nomegestrol, chlormadinone, and cyproterone acetate) are already known to increase the risk of meningioma.

New research has revealed a potential connection between certain progestins and meningioma risk, with implications for prescribing contraception in women women aged > 45 years.