To prove this idea, researchers designed a very interesting experiment. They used formaldehyde to cross-link proteins to kDNA in a reversible fashion. Commonly used to preserve or fix tissues for ...

But what about protein occupancy in a living cell? Orlando and Paro's idea was simple: Crosslink protein-DNA complexes using formaldehyde, immunoprecipitate with an antibody to the protein of interest ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...