C3(H 2 O) will bind to these platforms and will initiate local complement activation and C3b deposition. The amplification loop will generate C3a and C5a, which upon binding to their receptors ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

directly through the use of antibodies that disrupt the function of the receptor and/or induce Fc effector functions, such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent ...

A new study found that stimulating CB2, a receptor involved in immune cell function, improved cognitive performance in Alzheimer's disease (AD) mouse models. Researchers showed that activating CB2 ...

Despite the failure of an eczema trial in December, Q32 Bio is sticking with bempikibart. But a phase 2-stage complement inhibitor and a number of the biotech’s “valued colleagues” won’t be so lucky.

Here we describe a mouse Fc receptor, designated Fcα/μR, and its human homolog, that bind both IgM and IgA with intermediate or high affinity. Fcα/μR is constitutively expressed on the ...

In nine out of ten patients with type 2 diabetes, severe obesity, known as adiposity, leads to diabetes. Type 2 diabetes is ...

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.

Q32 Bio (QTTB) announced a corporate restructuring to focus on the advancement of its bempikibart clinical development program for the ...

If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

Discover the role of phytoestrogens, including soy, in menopause management and breast cancer prevention. Learn how these ...