Understanding the material basis of adaptive evolution has been a central goal in biology dating back to at least the time of ...

Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process can lead to cell death or diseases like cancer. A new study has shown ...

The incidence of Human Papillomavirus (HPV)–associated oropharyngeal cancers—tumors of the back of the mouth and throat—is ...

“This is the first comprehensive study of the frequency of extrachromosomal DNA found in diverse cancer types,” Charles Swanton, who studies cancer diversity at the Francis Crick Institute in the U.K.

One researchers explained that bacteria do a really, really good job of keeping the sequence you want and the sequence that you get.

Resulting gaps are filled in by DNA polymerases; this reaction leaves a nick at or flanking the site of repair. An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA ...

How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the ...

In contrast to chromosomal DNA, which is replicated and divvied up equally among daughter cells during cell division, the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split ...

Through this approach, we aim to understand how faithful and efficient chromosomal DNA replication is achieved under normal conditions and, conversely, how the replication machinery is affected by and ...

The authors further noted, “PDOs and tissues harboring MYC on ecDNA displayed significant heterogeneity of MYC copy number and expression, compared with tumors having MYC on chromosomal DNA.” ...