资讯

生物通9 天
综述：癌症免疫中的 cGAS-STING 通路：机制、挑战与治疗意义
这篇综述聚焦癌症免疫中 cGAS-STING 通路，深入剖析其激活免疫反应、发挥抗肿瘤作用的机制，探讨在癌症治疗中的应用、STING 激动剂的研发进展，分析面临的挑战，为癌症免疫治疗提供新思路，文章发表在《Journal of Hematology & Oncology 》上值得一读。 癌症免疫中的 ...
生物通1 个月
综述：靶向 cGAS-STING 通路重编程肿瘤相关巨噬细胞以增强抗肿瘤免疫 ...
本文聚焦 cGAS-STING 通路重编程肿瘤相关巨噬细胞（TAMs），探索其增强抗肿瘤免疫治疗的潜力。 ### 一、抗肿瘤免疫治疗面临的挑战与机遇 在全球范围内，抗肿瘤治疗始终是一项极具挑战性的任务。当前，手术、放疗、化疗、免疫治疗等多种手段被广泛探索应用于 ...
EurekAlert!11 个月
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor ...
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...
来自MSN11 个月
Unlocking the immune system: cGAS-STING pathway offers new hope for cancer treatment
The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...
EurekAlert!1 年
cGAS-STING pathway response model for micronucleus (IMAGE)
An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...