All lymph node biopsy samples were stained for CD19 (pan B-cell marker), CD20 (pan B-cell marker), CD138 (plasma cells), CD23 (follicular dendritic cells (FDCs)), PD-1 (follicular T helper cells, TFH) ...

Novel clinically relevant therapies based on CD19 ... cells without the requirement of MHC‐mediated antigen presentation (144). Odronextamab (REGN1979) is a first-in-class, hinge-stabilized, fully ...

Dublin, Feb. 11, 2025 (GLOBE NEWSWIRE) -- The "Cell Surface Markers Detection Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2020-2030F" report has been added to ...

The pre-B-cell receptor (pre ... Igα–Igβ heterodimer on the cell surface. SYK-dependent signals from the pre-BCR then feed into the PI3K pathway through CD19 and/or BCAP, leading to the ...

Here, we review the ongoing developments with CAR T cells in the field of autoimmune disorders. We will cover first clinical results of applying anti-CD19 and anti-B cell maturation antigen CAR T ...

Larger antigens, including antigen in immune complexes, can be presented to B cells on the surface of cells, such as dendritic cells, macrophages and follicular dendritic cells (FDCs). These ...

Rituximab, a chimeric anti-CD20 monoclonal antibody, is used to deplete mature B cells and reduce the production of autoantibodies. About 98.6% patients exhibited depletion of peripheral blood CD19 + ...

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

showed that the tandem CD19- and CD20-directed CAR T-cell therapy zamtocabtagene autoleucel (zamto-cel; MB-CART2019.1) induced responses, including durable complete responses (CRs), in patients with ...

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So B-cell maturation antigen is an evolving field where we have three ways of targeting this receptor, including the antibody direct conjugate, as well as the chimeric antigen receptor T-cell ...