Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

In current cancer therapy, cellular senescence is, on the one hand, intended to occur in tumor cells, as thereby the therapeutic outcome is improved, but might, on the other hand, also be induced ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Jan. 23, 2025 — There's a downside to being a powerful alpha male -- at least if you're a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of ...

In this murine orthotopic transplantation model for peritoneal carcinomatosis, we could show that the metastatic site in the peritoneum is responsible for senescence and stemness induction in tumor ...

Institute of Clinical Medicine, Central People’s Hospital of Zhanjiang, Zhanjiang, China Department of Endocrinology and Metabolism, Central People’s Hospital of Zhanjiang, Zhanjiang, China In this ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

Furthermore, cellular senescence, driven by DNA damage and disrupted cell cycle regulation, is a key hallmark of aging. Understanding the pathways and metabolites that contribute to senescence is ...

It feels like the Splinter Cell remake has been on its way for a while now, which isn't helped by the fact it's been over three years since we heard anything official about the game. From what we ...