The AWS Cloud Development Kit (AWS CDK) is an open-source software development framework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level ...

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p27 (also known as KIP1, and encoded by CDKN1B) is regulated by multiple signal transduction pathways in normal and malignant cells. CDKN1B transcription can be regulated by the FoxO family and ...

Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of proteins known as CDK-like (CDKL) kinases. The current ...

To this end, the company is “prioritizing further investment in its CDK franchise for breast cancer and other solid tumors to these programs.” The pipeline changes come a year after Blueprint ...

Eventually, in the form of p15-cyclinD/CDK4/CDK6 or p21/p27-cyclinE/CDK2, the G0/G1 phase is blocked and the proliferation of HCC cells is inhibited. Interestingly, in ATLL, CADM1 along with the ...

It’s going to take more than an oil-friendly administration to increase production. Gillette, Wyoming-based Cycline Drilling operates a rig in the Powder River Basin. (Courtesy Cyclone Drilling) The ...