MYSM1 mediates PARP1-dependent parthanatos in hypertrophic cardiomyocytes. This study presents a novel and promising therapeutic approach for cardiac hypertrophy by targeting the MYSM1-PARP1 axis, ...

Luteolin dose-dependently blocked phenylephrine-induced cardiomyocyte hypertrophy and showed extensive cardioprotective roles in cardiomyocytes as evidenced by transcriptomics. More importantly, ...

80466 Commercial assay or kit Micro-insert 4 well in µ-dish 35 mm ibidi, Cat. 80406 Chemical compound, drug Rhodamine-phalloidin Invitrogen, Cat. R415 1 in 500 Chemical compound, drug ...

Pathological growth of cardiomyocytes during hypertrophy is characterized by excess protein synthesis; however, the regulatory mechanism remains largely unknown. Using a neonatal rat ventricular ...

In this study, we sought to rapidly detect patterns of cardiotoxicity using high-content image analysis with deep learning and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). We ...