GCs are segregated into dark zones, in which B cells proliferate and mutate their antibody receptors, and light zones, in which B cells undergo selection processes through interactions with Tfh cells ...

Tfh express specific transcription factors and cellular receptors including Bcl6, CXCR5, PD-1, and ICOS, which are critical for homing and overall function. Generally, the induction of an immune ...

Tfh cells are involved in the development of autoimmune and allergic diseases, including rheumatoid arthritis, systemic lupus erythematosus, and allergic asthma (10). Mouse models of allergic asthma ...

Follicular T helper cells (Tfh) are a specialized subset of CD4 effector T cells that are crucial for germinal center (GC) reactions and for selecting B cells to undergo affinity maturation. Despite ...

Wiskott-Aldrich syndrome (WAS) is an immune pathology associated with mutations in WAS protein (WASp) or in WASp interacting protein (WIP). Together with the small GTPase Cdc42 and other effectors, ...