Northwestern Medicine scientists have discovered that inhibiting the GATA6 protein in mouse models of colon cancer reduced ...
为探究乳腺癌对缺氧的适应机制,研究人员研究 HIF1α-ATF3-P4HA1 轴,发现其促进癌细胞侵袭,为治疗提供靶点。 在肿瘤的 “小世界” 里,乳腺癌细胞正经历着一场特殊的 “考验”—— 缺氧。肿瘤不断生长,内部的代谢和血管出现异常,导致缺氧区域逐渐形成。缺氧就像一个幕后 “操纵者”,它能改变癌细胞的各种行为,比如让癌细胞更容易从原发部位 “跑” 到身体其他地方,也就是发生侵袭和转移,还能帮助 ...
为解决传统 DNA 甲基化检测技术的局限,英国巴斯大学研究人员开展 5mC 和 5hmC 纳米孔测序研究。结果显示该技术检测准确,还能研究修饰对称性。这为相关领域提供新方法,极具科研价值,推荐大家阅读。
当研究人员第一次绘制人类基因组图谱时,他们震惊地发现只有2%的DNA是编码蛋白质的"明码区段(coding regions)",其余98%的"暗物质(dark matter)"——也就是非编码区(noncoding ...
These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...
According to World Health Organization (WHO), cancer is the leading cause of death for children and adolescents. Leukemias, brain cancers, lymphomas and solid tumors, such as neuroblastoma, ...