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Specific inhibitors were used to block the activity of different kinases ... Filters were blocked with 10% non-fat powder milk or 5% bovine serum albumin (BSA) in Tris-buffered saline (TBS)-0.1% Tween ...

However, the role of small extracellular vesicles (sEVs; also known as exosomes) secretion in determining the cellular content and function of miRNAs in exosome-receiving cells ... Sections were ...

Moreover, activation of Rac1 in knee joints by CA-Rac1 lentivirus accelerated OA progression, while inhibition of Rac1 activity by DN-Rac1 lentivirus or Rac1 inhibitor NSC23766 delayed OA development ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

Several clinical trials investigate the efficacy of GEM in combination with targeted drugs, including kinase inhibitors, but the experimental evidence for such rationale is often unclear. Here, we ...

The A/G ratio describes the amount of albumin compared to the amount of globulin in your blood. Both are called serum proteins. They have different purposes in the human body, as follows: Under normal ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Sections were deparaffinised, rehydrated and blocked with 3% bovine serum albumin (BSA) prior to incubation with bHABP (1:200 in 1% BSA) overnight at 4°C. Remaining steps were carried out using ...