As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

Histones consisting of H2A, H2B, H3, and H4 are proteins that are critical in the packing of DNA into the cell. Lysine residues in N-terminal tails of histone H3 are the major targets for ...

Importantly, the team identified specific interactor proteins that only recognise the bivalent state ... space of the nucleus, histone proteins are also the site of modifications, chemical ...

Materials and methods: Here, we developed a novel bivalent mRNA vaccine, RBMRNA-405, comprising a 1:1 mix of mRNAs encoding both Delta-derived and Omicron-derived Spike proteins. We evaluated the ...

Chemical modification describes the modification, addition or removal, through chemical reaction, of any of a variety of macromolecules, including proteins and nucleic acids. It refers to the use ...

Drugs aimed at histone modifications are called histone deacetylase (HDAC) inhibitors. HDACs are enzymes that remove the acetyl groups from DNA, which condenses chromatin and stops transcription.