In TP53 wild-type HCC cells, HIF1α induced TP53-mediated inhibition of HIF1α-induced USP22 upregulation. In TP53-mutant HCC cells, USP22 and HIF1α formed a positive feedback loop and promote the ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Two spiritual practices that appear vastly different on the surface – the quiet focus of Buddhist jhāna meditation and the ...

Our biological sciences students explore the complexities of life and work to address global challenges in biology. Our faculty advance knowledge in a wide range of disciplines within the biological ...

Feb. 12, 2025 — Scientists have uncovered the equipment that enables bacteria to survive exposure to antibiotics: a shuttling mechanism that helps a complex of proteins pump out a wide spectrum ...

More crevasse activity could lead to positive feedback loop threatening Greenland glacier's stability. In just five years, 930 million cubic meters of crevasses opened up in the Greenland ice ...

The lab of Dr. Mark Magnuson, Louise B. McGavock Professor and professor of molecular physiology and biophysics at Vanderbilt ...

Obesity is more than just a diet and exercise issue; it's deeply intertwined with psychological and social factors. Experts ...

Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and ...