肿瘤促进癌基因的体细胞拷贝数扩增是癌症发病机制的主要驱动因素，高拷贝扩增通常集中在特定基因组区域。目前已知两种主要的高拷贝数癌基因扩增机制：染色体外 DNA（ecDNA）和断裂融合桥（BFB）循环。ecDNA 能够独立复制、随机分离，并通过多种机制介导对靶向治疗的抗性，携带 ecDNA 的患者预后较差。BFB 循环由 Barbara McClintock 在近 80 年前提出，它始于 DNA ...

The winning numbers in Wednesday evening’s drawing of the "Illinois Pick 4 Evening" game were: (one, six, seven, nine, Bonus: five) ...

The winning numbers in Monday evening’s drawing of the "Georgia Cash 3 Evening" game were: 2, 3, 3 (two, three, three) ...

For the first time in recent history, the percentage of top-grossing films featuring female protagonists equaled the percentage of films with male protagonists, according to a ...

Responding to questions from Sen. Andy Kim, Democrat of New Jersey, Powell said that the Fed is not overstaffed—“overworked, ...

The number of Americans filing new applications for unemployment benefits increased moderately last week, consistent with ...

Some Freeman Health System employees dressed in red recently to raise awareness about the number one killer of women in ...

Refers to the latest 2 years of stltoday.com stories. Cancel anytime. The winning numbers in Saturday's drawing of the "Illinois Lotto Million 2" game were: 4, 16, 27, 32, 40, 46 (four, sixteen, ...

A report from global outplacement firm Challenger, Gray & Christmas on Thursday showed U.S. employers announced plans to hire ...

The NCAA has changed its participation policy for transgender athletes, limiting competition in women’s sports to athletes ...