Table 1 Antibody-mediated and genetic depletion models for the in vivo study of basophils in different pathological conditions. The authors also evaluated the cytokines produced in the heart 3 days ...

Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, ...

C. Ohnmacht et al., “Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths,” Immunity, 33:364-74, 2010. Free F1000 Evaluation Basophils were deemed critical in ...

Chemokines facilitate leukocyte migration and positioning as well as other processes such as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines and their receptors ...

Asthma is one of the major growth areas in therapeutics and many new drugs are currently in development. These drugs include improvements of existing classes of drugs, notably once-daily inhaled ...

Nat Clin Pract Gastroenterol Hepatol. 2009;6(5):267-278. A thorough history and assessment of allergic diseases is a vital part of the evaluation of a patient with suspected EoE because of the ...

3 University of Colorado School of Medicine, Aurora, Colorado, USA Objective Eosinophils reside in the colonic mucosa and increase significantly during disease. Although a number of studies have ...