BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of ...

Among patients with early-stage triple-negative breast cancer, a beneficial pathologic complete response rate was higher in ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA ...

New findings could help identify patients likely to become resistant to anti-cancer drugs and aid exploring different ways to ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as ...

Around 50 out of 100 women with either a BRCA1 or BRCA2 gene mutations will get breast cancer by the time they are 70, while only to only 7 out of 100 women without the gene will develop cancer in ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Genetics significantly impact cancer risk, particularly in inherited mutations like BRCA1/BRCA2, which increase susceptibility to breast and ovarian cancer. Expert advice suggests that understanding ...