4). When initiated at the pro-B-cell stage, successful recombination of the IgH gene results in the expression of Igμ together with SLC and the Igα–Igβ heterodimer on the cell surface.

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...

The ability to efficiently isolate antigen-specific B cells in ... to remove cell aggregates. The second filtration was done immediately prior to sorting. Prior to sorting, an appropriate number of ...

The authors started with a comprehensive overview of the developmental trajectory of B cells, with their origin in the bone marrow and culminating in their migration to the peripheral. This journey is ...

Feb. 20, 2025 — Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

If you’re looking for a great thin and light laptop similar to something like Apple’s MacBook Air or Dell’s XPS laptops, then you may also want to consider Microsoft’s Surface laptops.

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

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This important study explores the conserved role of IgM in both systemic and mucosal antiviral immunity in teleosts, challenging established views on the differential roles of IgT and IgM. The ...