Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

The Midlands Integrative Biosciences Training Partnership is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham, Leicester, Aston, Harper Adams and Coventry.

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been ...

These results suggest that, in the recruitment of K63 and K27 ubiquitin chains to PDE9A, CHIP triggers its sequential ubiquitination and subsequent degradation via the autophagy–lysosomal pathway.

They were also able to artificially create these conditions and thus trigger the degradation of otherwise non-degradable molecules in yeast cells. Targeting autophagy in this way is a promising ...

Autophagy targets a range of intracellular components including a part of the nucleus that stores important chromosomes. However, the physiological significance of autophagic degradation of the ...

Florian Wilfling from the Max Planck Institute of Biophysics in Frankfurt has now discovered the conditions necessary for autophagy to start. They were also able to artificially create these ...

Rachel Maddow remarks on Donald Trump's embrace of the January 6 rioters and the insurrectionist militias that have declared themselves for him, pointing out on this peaceful January 6th the new ...