This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Similar to a small cut that heals itself after a short time, individual cells in our body suffer "wounds" in their protective ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu 610041, China Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been ...

Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, ...

These results suggest that, in the recruitment of K63 and K27 ubiquitin chains to PDE9A, CHIP triggers its sequential ubiquitination and subsequent degradation via the autophagy–lysosomal pathway.

They were also able to artificially create these conditions and thus trigger the degradation of otherwise non-degradable molecules in yeast cells. Targeting autophagy in this way is a promising ...