1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

Autophagy is an intracellular process that targets various cargos for degradation, including members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double-stranded DNA and triggers ...

Autophagy is a highly conserved catabolic process that involves an intracellular degradation system in which cytoplasmic components, such as protein aggregates, organelles, and other macromolecules, ...

Interestingly, in the same system, serum-starvation-induced autophagy did not lead to the elimination of catalase nor to cell death, indicating that catalase degradation is strongly tied to cell ...

Autophagy is a vital cellular process that involves the degradation and recycling of cellular components, playing a crucial role in maintaining cellular health. In the context of cancer ...

This Patent Highlight explores two groundbreaking approaches in TPD: bifunctional degraders that leverage the autophagy pathway via the p62 adaptor protein and substituted oxazolone compounds designed ...

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...

These results suggest that, in the recruitment of K63 and K27 ubiquitin chains to PDE9A, CHIP triggers its sequential ubiquitination and subsequent degradation via the autophagy–lysosomal pathway.

(5) The authors have shown nuclear inclusion formation and aggregation of mHTT and also commented on its potential removal with the UPS system (proteasomal degradation) in vivo. As there is also a ...

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...