Furthermore, inhibition of NF-κB in vitro leads to enhanced apoptosis in response to a variety of different stimuli. We show here that inhibition of NF-κB through the adenoviral delivery of a ...

Apoptosis can be triggered by the immune system or by the interaction of viral proteins with host signalling pathways. Inhibition of apoptosis has mixed effects on viral titre but typically has a ...

Apoptosis Market size is expected to reach ... accepted the New Drug Application for lisaftoclax, a Bcl-2 selective inhibitor for treating chronic lymphocytic leukemia/small lymphocytic lymphoma.

zju.edu.cn Objective Raf kinase inhibitor protein (RKIP) appears to control cancer cell metastasis and its ... RKIP deficiency inhibits DSS-induced or TNBS-induced colonic epithelial barrier damage ...

Danés, principal investigator of the Cancer and Stem Cell Biology Lab at the Champalimaud Foundation, in Lisbon, has shown ...

The absent, small or homeotic-like 1 (ASH1L) protein regulates the expression of HOXA genes, which are critical for the development of MLL1 translocations frequently found in leukemia patients.

Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

In this study, we evaluated the protein expression of XIAP in HCC tissues of patients. The in vivo effect of the XIAP inhibitor AZD5582 on cell proliferation, migration, and apoptosis of HCC cell ...

Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance ...

DelveInsight’s, “HDAC Inhibitor Pipeline Insight” report provides comprehensive insights about 40+ companies and 50+ pipeline ...

These inhibitors included necrostatin-1 (a necroptosis inhibitor), ferrostatin-1 (a ferroptosis inhibitor), N-acetyl cysteine (an inhibitor of oxidative stress-induced death), Z-VAD-FMK and Boc-D-FMK ...