Alpha measures a manager's skill in adding value to a portfolio beyond market gains. Beta assesses how a stock or fund's volatility compares to the market average. High alpha and low beta indicate ...
Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is specifically expressed in the heart. They found that the enzyme may prevent a ...
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It should be noted that Nuvation Bio (NUVB) has submitted an NDA for its dual tropomyosin receptor kinase (TRK)/ROS1 inhibitor taletrectinib in the treatment of line agnostic ROS1+ NSCLC with a ...
Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention, or ...
Department of Pediatrics, Shandong Province Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China Dilated cardiomyopathy (DCM) in children is a severe myocardial disease ...
This suggests KLF4 in SMC as a potential therapeutic target for inducing smaller and more stable lesions (25). Furthermore, the KLF4 reduction promoted by angiopoietin-like 4 (ANGPTL4)-transforming ...
The term dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders that are characterized by ventricular dilation and depressed myocardial performance in the absence of ...
A team has now identified an enzyme, alpha-kinase 2 (ALPK2), that is specifically ... had increased phosphorylation of the amino acid tropomyosin 1 (TPM1), a major regulator of heart contraction.