Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

The mechanism is thought to involve reduction in vascular nitric oxide by increased ... with reported improvement in both left ventricular ejection fraction and maximum oxygen consumption in patients ...

A groundbreaking study in Nature Cardiovascular Research uncovers promising drug targets for heart failure (HF) and its ...

Aldosterone escape and ... the continued high mortality rates in heart failure patients despite the advances made in pharmacotherapy. These mechanisms revealed the incomplete blockade of the ...

I am a cardiology researcher, and my team and I uncovered key mechanisms contributing to the harmful effects of obesity on heart function. Targeting these processes may offer new avenues for ...

Although the underlying mechanisms and mediators of arterial stiffness are not well understood, accumulating evidence supports the role of insulin resistance and endothelial dysfunction. The local ...

Feb. 11, 2025 — Patients aged between 50 to 70 years with a mechanical heart valve replacement had better long-term survival compared to those with a biological valve, new research has ...

By delving into the molecular mechanisms behind irregular heart rhythms, researchers can develop more targeted approaches that address the root causes and improve outcomes for patients struggling ...

Glucose and insulin tolerance tests were performed at the end of each week and blood and urine collected for measurements of plasma aldosterone, renin activity, electrolytes, insulin, and lipoproteins ...

Heart failure is a condition that occurs when the heart can’t pump as well as it should. This may happen when the heart muscle becomes weak or stiff. As a result, it doesn’t deliver enough blood to ...

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