为解决骨肉瘤治疗难题，武汉大学人民医院的研究人员开展 HMGCL 在骨肉瘤中作用的研究。结果发现 HMGCL 可抑制骨肉瘤进展，或为新治疗靶点。推荐科研读者阅读，助于了解骨肉瘤治疗新方向，开拓研究思路。

（四）TMEM45A 通过激活 AKT/mTOR 信号通路促进乳腺癌帕博西尼耐药和糖酵解 GSEA 分析发现，TMEM45A 高表达与 mTORC1 信号通路上调相关。Western blotting 显示，耐药细胞中 AKT/mTOR 信号通路激活，敲低 TMEM45A 降低 p-AKT 和 p-mTOR 表达，恢复帕博西尼对该通路的抑制 ...

We also created inducible cartilage-specific PPARγ/mammalian target for rapamycin (mTOR) double KO mice to dissect the PPARγ signalling pathway ... and determined the expression of poly (ADP-ribose) ...

Design Human HCC cell lines and HCC mouse models were used to assess the therapeutic efficacy and targeted molecular pathways of cabozantinib, either alone or in combination with the pan-mTOR ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. mTOR plays a pivotal role in cancer growth ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The problem of microplastics (MPs) pollution has caused many health risks to residents ...

On a recent winter afternoon in downtown Truckee, the sun dipped behind the mountains as a full moon rose above Donner Pass Road, the California city’s main thoroughfare. As the temperature ...

we found that ADM2 facilitates the expression of insulin-like growth factor 2 (IGF-II), which then triggers the activation of the AKT-GSK3β-mTOR signaling pathway via the IGF-II receptor (IGF-IIR ...

The Western genre is one of the oldest and cherished film genres to ever enter the landscape of cinema and successfully transitioned into the Talkies, only growing immensely popular among movie goers.

Sodium cantharidate (SCA) is a derivative of cantharidin obtained by its reaction with alkali. Studies have shown that it inhibits the occurrence and progression of several cancers. However, ...