Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

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In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

为解决癌症治疗难题，杰克逊基因组医学实验室研究人员开展 TRA2β - PE 相关研究。他们发现靶向 TRA2β - PE 的 ASO 能抑制癌细胞生长。这为癌症治疗提供新思路，强烈推荐科研读者阅读。

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Given that the role of PRMT1 in metabolic regulation has been well-documented, we then investigated whether PRMT1 is involved in transforming 6133 cells through metabolic reprogramming. To assess this ...

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Omar Marmoush scored a sensational first-half hat-trick to sink Newcastle United as the Egyptian announced himself at Manchester City. Substitute James McAtee added a late fourth as City made ...