Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme, which converts GTP to the second messenger cGMP in response to signalling from gaseous ligands, particularly nitric oxide (NO).

Our strain collection includes strains expressing each of the 10 mammalian adenylyl cyclases as well as wild-type and mutationally-activated forms of the human GNAS Gα. A recent screen of ~125,000 ...