Figure 2. Schematic diagram of the DNA methylation process. Cytosine is methylated by DNMTs (DNMT1, DNMT3a and DNMT3b) to produce 5-methylcytosine (5-mC). 5-mC can be reduced to cytosine by active ...

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For example, drugs that target and inhibit exonuclease proofreading or template switching between polymerase and exonuclease active sites might effectively inhibit DNA synthesis and the repair of ...

The behavior of a person's genes doesn't just depend on the genes' DNA sequence - it's also affected by so-called epigenetic factors. Changes in these factors can play a critical role in disease.

Background: DNA methylation played essential roles in regulating gene expression. The impact of DNA methylation status on the occurrence and development of cancers has been well demonstrated. However, ...

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SLE patients (n = 3389) who had undergone hysterectomy were less likely to develop nephritis or positive anti-double-strand DNA antibodies ... with moderately active SLE produced a significant ...

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...

Objective Rheumatoid arthritis (RA) is characterised by chronic inflammation leading to articular bone and cartilage damage. Despite recent progress in RA management, adverse effects, lack of efficacy ...