With its discovery of small molecules that activate RNA methylation, the biotech has broken new ground in epitranscriptomics. This breakthrough positions Chemestmed to advance candidates with the ...

The central dogma of molecular biology suggests that the primary role of RNA is to convert the information ... often resulting in the methylation and pseudouridylation of specific nucleosides.

But these information molecules are much more than their core sequences. A variety of chemical modifications decorate the nucleic acids, increasing the alphabet of DNA to about a dozen known ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a ...