在探索神经节律性调节的分子机制中，来自美国西奈山伊坎医学院的研究团队在 Nature 期刊上发表了一项题为“Bidirectional histone monoaminylation dynamics regulate neural ...

Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional ...

Although this hypothesis is attractive in its simplicity with respect to the propagation of histone PTMs, it is difficult to conceive of how each H3–H4 dimer or tetramer would be deposited after ...

More information: Cyril S. Anyetei-Anum et al, Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression, Genes & Development ...

The teams found that TG2 acts as a regulator of intracellular monoamine neurotransmitters with an ability to not only add monoamines to histone H3 but also erase and exchange one monoamine ...