However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis.

Acute leukemia, a type of cancer that affects the blood and bone marrow, can present with a variety of symptoms, including musculoskeletal (MSK) manifestations. In pediatric patients, these ...

Auron Therapeutics Inc. has received FDA clearance of its IND application for its oral KAT2A/B degrader AUTX-703 in hematological malignancies. A phase I proof-of-concept trial in acute myeloid ...

The disease manifests in various subtypes, the most common being acute lymphoblastic leukemia (ALL) and acute myeloid ...

The team identified a specific population of immune cells that play a critical role in successful treatment of relapsed acute myeloid leukemia (AML). A research team from Columbia Engineering and ...