Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in ...

We study how the transcriptional networks are rewired in cancer cells, and how this rewiring could be exploited as cancer therapy. The major disease model of interest is prostate cancer, and ...

This mutation is directly linked to transcriptional activity: the more a promoter is active, the more frequently mutations appear in this promoter. In experiments where transcriptional activation ...

More information: Masahito Yoshihara et al, Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders, EMBO Reports (2025). DOI: 10.1038/s44319-025-00372-1 ...

The researchers then evaluated the similarities between the TC and LE regions from the 12 patient tissue sections in terms of their transcriptional profiles. They found that gene expression was highly ...

statuses to understand the transcriptional landscape regulating PDAC development and identify novel therapeutic targets.

A recent study has shed light on the transcriptional regulatory mechanisms of Penicillium expansum, the fungal culprit behind ...

Researchers identified a monocyte/dendritic cell response to EBV reactivation in B cells as one of the earliest events in ...

A new study by LMU and Helmholtz Munich shows how the pathogen Trypanosoma brucei controls changes in its cell surface to evade the immune ...