研究人员针对病毒治疗难题，开展脂质纳米颗粒（LNP）递送抗病毒 siRNA 研究，发现该疗法效果显著 ... 的研究人员开展了一项关于利用脂质纳米颗粒（Lipid Nanoparticles，LNPs）递送抗病毒小干扰 RNA（short - interfering RNAs，siRNAs）的研究。该研究成果发表在《Drug ...

To overcome these barriers, many siRNA delivery systems have been developed. Among these, lipid-based nanoparticles have great potential owing to their biocompatibility and low toxicity in ...

decreased toxicity and improved siRNA delivery to the cytoplasm. Lipoprotein-based nanoparticles with excellent biocompatibility, favorable pharmacokinetics, nonimmunogenicity, suitably small size ...

has demonstrated for the first time that intraperitoneal administration of chitosan nanoparticles containing TNF-specific small interfering RNA (siRNA) could be used to reduce TNF-mediated ...

The liver is an attractive target for siRNA delivery because of its important role in numerous diseases and because of the ease at which hepatocytes take up nanoparticles after simple injection.

Just as the use of RNA interference has mushroomed throughout the world over the last six years, the number of bioinformatics tools to screen for siRNA has blossomed, too. More than a half-dozen ...

Generation Bio's innovative approach leverages cell-targeted lipid nanoparticles (ctLNP) to selectively deliver small interfering RNA (siRNA) to T cells. This combination of selective delivery and an ...

"Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer." How would you summarize your study for a lay ...