Stimulating a receptor in adipocytes enhanced energy expenditure and caused sustained weight loss in mice, offering targets ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

Trop-2 overexpression has been proposed as a marker for biologically aggressive tumor phenotypes. Methods Trop-2 protein expression was quantified using tissue microarrays consisting of formalin ...

Results from high-fat diet mice showed that overexpression of gastric leptin that is linked to gut ‘5HT pathway’ occurred before the onset of obesity and expansion of fat mass. This may be ...

Researchers have developed innovative compounds capable of precisely targeting cancer cells when activated by light. This ...

Cyclo-oxygenase 2 (COX2) has a key proinflammatory role in the liver; however, it was not previously known whether COX2 activity alone was sufficient to induce hepatitis. Now, Yu and colleagues ...

Overexpression of focal adhesion kinase (FAK) has been observed in several types of cancer, including gastric, esophageal and colorectal cancers. Several FAK inhibitors have advanced to clinical ...