"Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to ...

Most pathological aggregates, called oligomers, are difficult to study with traditional methods, due to their fleeting nature and structural variability. Antibodies, known for their precise target ...

Expansion of trinucleotide repeats, such as CAG that encodes for polyglutamine, is associated with a number of neurodegenerative disorders. Expanded polyglutamine fragments form aggregates that have ...

elegans and mammalian neuronal cultures (Fonte et al, 2011). We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

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Yet as the different pathological roles of distinct Aβ species have become clearer, the possibility of selectively targeting specific types of Aβ, as with ACU193’s targeting of Aβ oligomers ...

Zervimesine is an investigational oral, once-daily pill being developed for the treatment of CNS diseases, including ...