elegans and mammalian neuronal cultures (Fonte et al, 2011). We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

"Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to ...

Yet as the different pathological roles of distinct Aβ species have become clearer, the possibility of selectively targeting specific types of Aβ, as with ACU193’s targeting of Aβ oligomers ...

Expansion of trinucleotide repeats, such as CAG that encodes for polyglutamine, is associated with a number of neurodegenerative disorders. Expanded polyglutamine fragments form aggregates that have ...

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Zervimesine is an investigational oral, once-daily pill being developed for the treatment of CNS diseases, including ...

Canadian biotech ProMIS Neurosciences has initiated a Phase Ib trial of its lead therapeutic candidate, PMN310, designed to treat Alzheimer’s disease by selectively targeting toxic oligomers of ...