Background and objectives Oxidative stress could be a key process in acyclovir (ACV)-induced nephrotoxicity. N-acetylcysteine ...

This study demonstrated that NAC supplementation prevented ACV-induced nephrotoxicity in rats in a dose-dependent manner, indicating potential therapeutic value for ACV-associated nephrotoxicity.

Background: The clinical evidence base for ototoxicity and nephrotoxicity outcomes with once-daily dosing (ODD) of gentamicin in children is suboptimal. Therapeutic drug monitoring (TDM ...