Figure 3: The Dnmt1-interacting region of HDAC1 associates with methyltransferase activity. We transiently transfected 293T cells in culture dishes (15-cm diameter) with pCMV-Myc-Dnmt1 (20 μg ...

Because methylation patterns in large part determine product outcome, subtle alterations in methyltransferase substrate selectivity have a profound impact on secondary metabolic activities in ...

Bacteriophages, the most abundant life form on Earth, infect bacterial cells and influence the structure of the microbial ...

In the Protein Engineering and Evolution Unit's latest publication in Nucleic Acids Research, the team presents an engineered RNA methyltransferase, which can be used to study the role of RNA ...