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靶向 mTOR 通路:对抗环磷酰胺所致卵巢损伤的新希望
抑制 mTOR 信号通路减轻颗粒细胞损伤:使用 mTORC1 抑制剂依维莫司(RAD001)处理培养的小鼠颗粒细胞,发现 p - Rps6 表达降低,γ - H2AX 阳性颗粒细胞比例减少,表明 mTOR 抑制对 DNA 损伤和细胞凋亡有保护作用。在体内实验中,注射 RAD001 和 CTX 的小鼠,其颗粒细胞中 ...
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