Protein stability can now be studied in a high-throughput ... separated by an internal ribosomal entry site on a single mRNA (Fig. 1a). EGFP is fused to the N terminus of the target protein ...

Microarray analyses have revealed that 40–50% of changes in gene expression in response to cellular signals occurs at the level of mRNA stability 87,88. These changes are usually induced by ...

To elucidate mRNA stability, the study identified that the binding of TRIM25, a cellular defense protein, to exogenous mRNAs induced rapid degradation to prevent function. mRNA containing the ...

This modification prevents TRIM25 from binding to mRNA, enhancing the stability and effectiveness of mRNA vaccines. This discovery not only explains how mRNA vaccines evade cellular surveillance ...

This modification prevents TRIM25 from binding to mRNA, enhancing the stability and effectiveness of mRNA vaccines. This discovery not only explains how mRNA vaccines evade cellular surveillance ...

This modification prevents TRIM25 from binding to mRNA, enhancing the stability and effectiveness of mRNA vaccines. This discovery not only explains how mRNA vaccines evade cellular surveillance ...