POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Prince Frederik of Luxembourg, who died at 22, spoke about the rare genetic disorder he navigated in a video released by The PolG Foundation he founded.

The prince had PolG disease, a genetic mitochondrial disorder that prevents the body's cells from producing adequate energy.

Prince Frederik, the son of Europe's Prince Robert of Luxembourg, has died from a rare genetic disease, his family announced.

Prince Frederik, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, died at age 22 on March 1 from the rare genetic condition POLG Mitochondrial disease.

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Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease.

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22, died from a mitochondrial disease known as PolG,