TLC’s Jay & Pamela introduced many viewers for the first time to osteogenesis imperfecta type 3, the super-rare genetic disorder stars Jay Manuel and Pamela Chavez were born with. Naturally, fans have many questions about the rare bone condition,

Jay & Pamela star Pamela Chavez has been estranged from her family amid her relationship Jay Manuel. Because her parents don’t approve of the romance, Pamela relocated across state lines to move in with Jay in the basement of his mom and dad’s home.

The married couple, who star in a new TLC series, were both born with a rare genetic disorder called osteogenesis imperfecta type 3.

In ET's exclusive look at TLC’s new series, ‘Jay & Pamela,’ a couple that shares the same rare brittle bone disease struggles to go grocery shopping. ‘Jay & Pamela’ airs Tuesday at 10/9c on TLC.