Researchers identify Lhx2 as key gene in hepatic stellate cells regulating liver regeneration and fibrosis
A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...
BioWorld13d
MEOX1 signaling behind the pathogenesis of IBD, study finds
Investigating the relationship between IL-1 and inflammation in inflammatory bowel disease (IBD), researchers unveiled mesenchyme homeobox 1 (MEOX1), an IL-1-dependent transcription factor that is ...
Medscape9d
Glucose Toxicity in Beta-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
The responsible metabolic lesion appears to involve a posttranscriptional defect in pancreas duodenum homeobox-1 (PDX-1) mRNA maturation. PDX-1 is a critically important transcription factor for ...