但希望之光已然显现：研究者通过腺相关病毒（AAV）基因治疗，将衰老小鼠脑血管的糖萼厚度恢复83%，不仅逆转血管渗漏，更让20月龄老年鼠在迷宫测试中展现超越年轻组的空间记忆能力。这项颠覆性发现不仅重新定义了血脑屏障的防御机制，更为对抗阿尔茨海默病开辟了全新治疗维度：修复纳米级的糖萼结构，或将成为阻止大脑"塌方式衰老"的关键突破口。

This research roundup explores the role of sugar molecules in brain degeneration, a machine learning algorithm to detect ...

Hamilton and McMichael 1 and Matthews 2 have recently suggested mechanisms to explain features of intestinal disaccharide absorption which are dependent on the structure of the microvilli and ...

In a study with aging mice, Shi discovered significant changes in the sugary coating (glycocalyx) on cells that form the ...

In a study in aging mice, Shi has uncovered striking age-related changes in the sugary coating—called the glycocalyx—on cells that form the blood-brain barrier, a structure that protects the brain by ...

Protecting the endothelial glycocalyx with a new therapy prevents diabetic microvascular complications, offering a systemic treatment approach.

Professor Bruce Turnbull The surface of every living cell is covered in a layer of complex carbohydrate structures known as the glycocalyx. The types of carbohydrates present differ from one cell type ...