We are currently investigating the precise molecular interactions that cause these high mutation rates and are now building principles to predict where these mutational hotspots may occur." ...

Patients with germline BRCA mutations who were diagnosed with breast cancer at or before age 40 and who underwent a bilateral risk-reducing mastectomy (RRM) and/or a risk-reducing ...

Six ATM germline variants were found among the 328 men tested for this genetic mutation. And among the ... given the high rates of overdiagnosis,” say the researchers. “It may be time ...