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Nat Commun:利用反义寡核苷酸增加TRA2β基因中的毒性外显子水平,可 ...
这项新研究的核心是称为毒性外显子(poison exon)的微小遗传元件,这是大自然自己的蛋白生产“开关”。当这些外显子包含在RNA信息中时,它们会在蛋白形成之前触发其破坏,从而防止有害的细胞活动。在健康细胞中,毒性外显子调节关键蛋白的水平,控制遗传机制。但在癌症中,这种安全机制经常失效。
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