A novel mechanism of DNA endonucleolytic cleavage has been visualized for the homing endonuclease I-PpoI by trapping the uncleaved enzyme–substrate complex and comparing it to the previously ...

Apurinic/apyrmidinic endonuclease 1 (APE1) plays a central role in DNA repair by cleaving the DNA backbone 5′ of AP sites that result from removal of damaged bases. New structural findings on ...