New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is ...

Apoptosis is executed by caspases, a mechanism conserved across species. However, caspases, a large family of cysteine proteases with aspartate substrate specificity, are synthesized in cells as ...