Here we show in animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase β-subunit (PDE-β) respectively, that rod bipolar cells received ...

The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular and vascular penile ...

Phosphodiesterase inhibition is of major interest in the pharmaceutical industry. Phosphodiesterase enzymes cleave the phosphodiester bonds in secondary intramolecular messengers like cyclic-AMP and ...